Ischemia-reperfusion injury, a common complication during liver surgery where steatotic livers are more prone to the injury, may become more prevalent in the growing obese population. This study characterizes liver morphology toward understanding changes in subcellular function in steatotic livers exposed to ischemiareperfusion injury through quantitative description of fluorescein distribution...

Takahashi, Yoshihito, Raymond W. Ganster, Andrea Gambotto, Lifang Shao, Takashi Kaizu, Tong Wu, Gautam P. Yagnik, Atsunori Nakao, George Tsoulfas, Takashi Ishikawa, Toyokazu Okuda, David A. Geller, and Noriko Murase. Role of NFB on liver cold ischemiareperfusion injury. Am J Physiol Gastrointest Liver Physiol 283: G1175–G1184, 2002. First published July 17, 2002; 10.1152/ajpgi.00515.2001.—The r...

SEE PAGE 47 A MP-activated protein kinase (AMPK) is a molecular energy sensor that is essential to the stress response in the heart (1). AMPK is activated during energy imbalance, when the ADPor AMP-toATP ratio increases. Because few proteins have adenine nucleotide binding domains, the activation of a protein kinase, which phosphorylates numerous downstream proteins, amplifies the energy stres...

This study aimed to investigate tourniquet-induced compartment syndrome of the limb, consequential development multiple organ dysfunction syndrome, and its counteraction with pentadecapeptide BPC 157 therapy.

Ischemia-reperfusion injury is a serious problem which can occur during lung transplantation. Preservation of pulmonary function by reducing ischemia-reperfusion injury is essential for successful lung transplantation. Although the mechanisms responsible for ischemia-reperfusion lung injury are not clear yet, it is commonly accepted that ischemic time, storage conditions and additive usage of s...

Purpose: The aim of this study was to investigate alterations compatible with hepatic ischemia-reperfusion after bilioduodenal shunt (BD) in rats with obstructive jaundice (OB) . Methods:Thirty six animals were divided into 6 experimental groups: CO1 and CO2 – control groups, sham-operated (SO) and evaluated 6 and 24 hours after, respectively; OB1 and OB2, – obstructive jaundice groups, sham-op...